Ondansetron Hydrochloride Syrup

Therapeutic Indication

Nausea and vomiting

Gastroenteritis-associated vomiting

Postoperative nausea and vomiting

Drug-induced nausea and vomiting

Gastric discomfort associated with vomiting

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Ondansetron Hydrochloride

Syrup

Ondansetron Syrup is an antiemetic formulation used for the prevention and treatment of nausea and vomiting associated with gastrointestinal infections, medication use, postoperative conditions, and other medical treatments. It works by blocking serotonin (5-HT3) receptors that trigger nausea and vomiting reflexes.
The formulation provides effective relief from vomiting and helps improve patient comfort and hydration, especially in pediatric and adult patients experiencing nausea due to various causes.

Speciality	Gastroenterology
Tags	Antiemetic \| Vomiting Relief \| Pediatric Care \| Gastro Care
Strength	Ondansetron Hydrochloride – 2 mg
Packing Size	30 ml Bottle

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Mechanism

Ondansetron works by selectively blocking serotonin (5-HT3) receptors located in the gastrointestinal tract and central nervous system, thereby preventing the initiation of the vomiting reflex.

Benefits

Provides effective relief from nausea and vomiting
Helps maintain hydration by controlling vomiting episodes
Improves patient comfort during gastric illness
Suitable for pediatric and adult use under medical supervision

Side Effects

Constipation
Headache
Dizziness

Pharmacokinetics

Absorption: Rapidly absorbed orally, peak plasma concentration in ~2 hours.
Distribution: Volume of distribution ~1.9 L/kg; widely distributed.
Metabolism: Extensively metabolized in the liver via CYP1A2, CYP2D6, and CYP3A4.
Excretion: Mostly excreted as metabolites in urine and feces; 10% unchanged.
Half‑life: 3–6 hours in adults; prolonged in hepatic impairment.

Contraindication

Hypersensitivity to Ondansetron or related compounds
Concomitant use with apomorphine
Severe hepatic impairment (use with caution)

Dosage

As directed by the physician.

DRUG INTERACTIONS

Apomorphine: Risk of severe hypotension
QT-prolonging drugs: Increased risk of arrhythmias
Serotonergic drugs: Increased risk of serotonin syndrome

Warning and Precautions

This has been prescribed for the patient's specific condition. It may be dangerous to any other person.

Use cautiously in patients with liver disorders
Monitor in patients with cardiac rhythm abnormalities
Use during pregnancy or lactation only under medical advice
Do not exceed recommended dose
Store in a cool, dry place away from direct sunlight
Keep out of reach of children

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.